Workpackage #1
Identify rare (& common) genetic variants associated with structural markers of brain aging.
Leadership: P5 & P2
We will search for genetic variants associated with established and novel MRI-markers of brain aging, focusing particularly on rare variants, using both agnostic and candidate locus approaches (loci identified through GWAS of AD or MRI-markers of brain aging). In contrast with GWAS signals, rare variants may lead to the discovery of causal variants, and have hardly been explored in association with structural MRI-markers.
Tasks associated to this work package are:
- WP1.1. Association of low frequency and rare variants with structural markers of brain aging
- WP1.2. Association of common and rare variants with novel structural markers of brain aging
- WP1.3. Spatial & temporal mapping of genetic determinants for structural markers of brain aging
