Clinical and functional significance of genetic determinants for structural brain aging
leadership P6 & P4
We will explore the clinical and functional significance of the genetic and epigenetic markers. We will examine their association with cognitive performance & decline and risk of dementia/AD, capitalizing on elaborate cognitive testing and prospective dementia surveillance. For functional exploration, we will utilize cutting-edge bioinformatic methods, large epigenome maps in multiple tissues including brain, and in vivo experimental verification of predicted molecular mechanisms using established in vivo assays in Drosophila.
Tasks associated to this workpackage are:
WP3.1. Association of genetic risk variants for structural markers of brain aging with cognitive performance & decline, and with incident dementia
WP3.2. Functional exploration of identified risk and protective variants